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داروی فعال
The prodrug is intended to interconvert within the body by specific enzymes to liberate the parent active drug.
Prodrug design comprises an area of research devoted to optimize drug delivery, where the pharmacologically inactive species required transformation within the body in order to release the parent active drug (Halen et al.
Usually, the use of the term implies a covalent link between a drug and a chemical moiety, though some authors also use it to characterize some forms of salts of the active drug molecule.
Although there is no strict universal definition for a prodrug itself, and the definition may vary from author to author, generally prodrugs can be defined as pharmaco- logically inert chemical derivatives that can be converted in vivo to the active drug molecules, enzymatically or non-enzymatically, to exert a therapeutic effect.
In simplified terms, prodrugs are masked forms of active drugs that are designed to be activated after an enzymatic or chemical reaction once they have been administered into the body.
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